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An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity
In cancer cells, glutaminolysis is the primary source of biosynthetic precursors, fueling the TCA cycle with glutamine-derived α-ketoglutarate. The enhanced production of α-ketoglutarate is critical to cancer cells as it provides carbons for the TCA cycle to produce glutathione, fatty acids, and nuc...
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| Yayımlandı: | RSC Adv |
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| Asıl Yazarlar: | , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Royal Society of Chemistry
2021
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7968037/ https://ncbi.nlm.nih.gov/pubmed/33777357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0ra08249j |
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