An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity

In cancer cells, glutaminolysis is the primary source of biosynthetic precursors, fueling the TCA cycle with glutamine-derived α-ketoglutarate. The enhanced production of α-ketoglutarate is critical to cancer cells as it provides carbons for the TCA cycle to produce glutathione, fatty acids, and nuc...

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Detalhes bibliográficos
Publicado no:RSC Adv
Main Authors: Hossain, Md Imran, Thomas, Ajit G., Mahdi, Fakhri, Adam, Amna T., Akins, Nicholas S., Woodard, Morgan M., Paris, Jason J., Slusher, Barbara S., Le, Hoang V.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2021
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968037/
https://ncbi.nlm.nih.gov/pubmed/33777357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0ra08249j
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