Human gut microbial communities dictate efficacy of anti-PD-1 therapy in a humanized microbiome mouse model of glioma

BACKGROUND: Although immunotherapy works well in glioblastoma (GBM) preclinical mouse models, the therapy has not demonstrated efficacy in humans. To address this anomaly, we developed a novel humanized microbiome (HuM) model to study the response to immunotherapy in a preclinical mouse model of GBM...

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Detalhes bibliográficos
Publicado no:Neurooncol Adv
Main Authors: Dees, Kory J, Koo, Hyunmin, Humphreys, J Fraser, Hakim, Joseph A, Crossman, David K, Crowley, Michael R, Nabors, L Burton, Benveniste, Etty N, Morrow, Casey D, McFarland, Braden C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7967908/
https://ncbi.nlm.nih.gov/pubmed/33758825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab023
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