Avidity‐Based Selection of Tissue‐Specific CAR‐T Cells from a Combinatorial Cellular Library of CARs

Using T‐cell chimeric antigen receptors (CAR‐T) to activate and redirect T cells to tumors expressing the cognate antigen represents a powerful approach in cancer therapy. However, normal tissues with low expression of tumor‐associated antigens (TAAs) can be mistargeted, resulting in severe side eff...

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Vydáno v:Adv Sci (Weinh)
Hlavní autoři: Ma, Peixiang, Ren, Ping, Zhang, Chuyue, Tang, Jiaxing, Yu, Zheng, Zhu, Xuekai, Fan, Kun, Li, Guanglei, Zhu, Wei, Sang, Wei, Min, Chenyu, Chen, Wenzhang, Huang, Xingxu, Yang, Guang, Lerner, Richard A.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7967050/
https://ncbi.nlm.nih.gov/pubmed/33747727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202003091
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