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In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
Cystobactamids are myxobacteria-derived topoisomerase inhibitors with potent anti-Gram-negative activity. They are formed by a non-ribosomal peptide synthetase (NRPS) and consist of tailored para-aminobenzoic acids, connected by a unique α-methoxy-l-isoasparagine or a β-methoxy-l-asparagine linker m...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7966384/ https://ncbi.nlm.nih.gov/pubmed/33727542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21848-3 |
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