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Photo-destruction of Stromal Fibroblasts Enhances Tumor Response to PDT in 3D Pancreatic Cancer Co-culture Models

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal of human cancers. The dismal response of PDAC to virtually all therapeutics is associated, in part, with a characteristically dense fibrotic stroma. This stroma acts not only as a barrier to drug perfusion, but also promotes tumor surv...

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Bibliographic Details
Published in:Photochem Photobiol
Main Authors: Karimnia, Vida, Rizvi, Imran, Slack, Frank J., Celli, Jonathan P.
Format: Artigo
Language:Inglês
Published: 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7965253/
https://ncbi.nlm.nih.gov/pubmed/33011973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/php.13339
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