Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody

The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population underscores the need for broadly active countermeasures. We employed a directed evolution approach to engineer three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies for enhanced neutralization...

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Pubblicato in:Science
Autori principali: Rappazzo, C. Garrett, Tse, Longping V., Kaku, Chengzi I., Wrapp, Daniel, Sakharkar, Mrunal, Huang, Deli, Deveau, Laura M., Yockachonis, Thomas J., Herbert, Andrew S., Battles, Michael B., O’Brien, Cecilia M., Brown, Michael E., Geoghegan, James C., Belk, Jonathan, Peng, Linghang, Yang, Linlin, Hou, Yixuan, Scobey, Trevor D., Burton, Dennis R., Nemazee, David, Dye, John M., Voss, James E., Gunn, Bronwyn M., McLellan, Jason S., Baric, Ralph S., Gralinski, Lisa E., Walker, Laura M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2021
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7963221/
https://ncbi.nlm.nih.gov/pubmed/33495307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abf4830
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