Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children

Morphine is a widely used opioid analgesic, which shows large differences in clinical response in children, even when aiming for equivalent plasma drug concentrations. Age-dependent brain disposition of morphine could contribute to this variability, as developmental increase in blood-brain barrier (...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Principais autores: Verscheijden, Laurens F. M., Litjens, Carlijn H. C., Koenderink, Jan B., Mathijssen, Ron H. J., Verbeek, Marcel M., de Wildt, Saskia N., Russel, Frans G. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7963108/
https://ncbi.nlm.nih.gov/pubmed/33661919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008786
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