Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis

Different pediatric physiologically-based pharmacokinetic (PBPK) models have been described incorporating developmental changes that influence plasma drug concentrations. Drug disposition into cerebrospinal fluid (CSF) is also subject to age-related variation and can be further influenced by brain d...

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Detaylı Bibliyografya
Yayımlandı:PLoS Comput Biol
Asıl Yazarlar: Verscheijden, Laurens F. M., Koenderink, Jan B., de Wildt, Saskia N., Russel, Frans G. M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592555/
https://ncbi.nlm.nih.gov/pubmed/31194730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007117
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