Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike (S) protein receptor-binding domain and block virus interactions with the cellular receptor angiotensin-converting enzyme 2. We describe a panel of human mAbs binding to diverse epitopes on the N-terminal domain (NTD...

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Vydáno v:Cell
Hlavní autoři: Suryadevara, Naveenchandra, Shrihari, Swathi, Gilchuk, Pavlo, VanBlargan, Laura A., Binshtein, Elad, Zost, Seth J., Nargi, Rachel S., Sutton, Rachel E., Winkler, Emma S., Chen, Elaine C., Fouch, Mallorie E., Davidson, Edgar, Doranz, Benjamin J., Chen, Rita E., Shi, Pei-Yong, Carnahan, Robert H., Thackray, Larissa B., Diamond, Michael S., Crowe, James E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Inc. 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962591/
https://ncbi.nlm.nih.gov/pubmed/33773105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.03.029
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