Immune Checkpoint Inhibition in Metastatic Colorectal Cancer Harboring Microsatellite Instability or Mismatch Repair Deficiency

SIMPLE SUMMARY: Microsatellite instability (MSI) is a molecular indicator of defective DNA mismatch repair (dMMR). MSI/dMMR status is observed in approximately 5% of metastatic colorectal cancers (mCRC) but 10–18% of localized colorectal cancers. MSI/dMMR status is a major predictive biomarker for t...

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Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Cohen, Romain, Colle, Raphaël, Pudlarz, Thomas, Heran, Maximilien, Duval, Alex, Svrcek, Magali, André, Thierry
Format: Artigo
Language:Inglês
Published: MDPI 2021
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962453/
https://ncbi.nlm.nih.gov/pubmed/33800202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13051149
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