Overexpression of Human ABCB1 and ABCG2 Reduces the Susceptibility of Cancer Cells to the Histone Deacetylase 6-Specific Inhibitor Citarinostat

Citarinostat (ACY-241) is a promising oral histone deacetylase 6 (HDAC6)-selective inhibitor currently in clinical trials for the treatment of multiple myeloma (MM) and non-small-cell lung cancer (NSCLC). However, the inevitable emergence of resistance to citarinostat may reduce its clinical effecti...

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Publicado no:Int J Mol Sci
Main Authors: Wu, Chung-Pu, Hung, Cheng-Yu, Lusvarghi, Sabrina, Chang, Yen-Fu, Hsiao, Sung-Han, Huang, Yang-Hui, Hung, Tai-Ho, Yu, Jau-Song, Ambudkar, Suresh. V.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961520/
https://ncbi.nlm.nih.gov/pubmed/33807514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22052592
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