A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

Tau inclusions are a shared feature of many neurodegenerative conditions and tau mutations lead to frontotemporal dementia. Approaches to treatment of these conditions have focused directly on the tau protein by targeting its post-translational modifications, its levels and its tendency to aggregate...

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Bibliografske podrobnosti
izdano v:Sci Transl Med
Main Authors: Hernandez, Israel, Luna, Gabriel, Rauch, Jennifer N., Reis, Surya, Giroux, Michel, Karch, Celeste M., Boctor, Daniel, Sibih, Youssef, Storm, Nadia J., Diaz, Antonio, Kaushik, Susmita, Zekanowski, Cezary, Kang, Alexander A., Hinman, Cassidy, Cerovac, Vesna, Guzman, Elmer, Zhou, Honjun, Haggarty, Stepphen J., Goate, Alison, Fisher, Steven K., Cuervo, Ana M., Kosik, Kenneth S.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961212/
https://ncbi.nlm.nih.gov/pubmed/30918111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aat3005
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