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Mice lacking DKK1 in T cells exhibit high bone mass and are protected from estrogen-deficiency-induced bone loss

The Wnt inhibitor Dickkopf-1 (DKK1) is a negative regulator of bone formation and bone mass and is dysregulated in various bone diseases. How DKK1 contributes to postmenopausal osteoporosis, however, remains poorly understood. Here, we show that mice lacking DKK1 in T cells are protected from ovarie...

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Bibliografski detalji
Izdano u:iScience
Glavni autori: Lehmann, Juliane, Thiele, Sylvia, Baschant, Ulrike, Rachner, Tilman D., Niehrs, Christof, Hofbauer, Lorenz C., Rauner, Martina
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961106/
https://ncbi.nlm.nih.gov/pubmed/33748710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102224
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