Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces

To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators. The dimeric modulator FHR-1 is hypothesized to competitively remove the complement regulator FH from surfaces that...

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Foilsithe in:Front Immunol
Main Authors: Dopler, Arthur, Stibitzky, Selina, Hevey, Rachel, Mannes, Marco, Guariento, Mara, Höchsmann, Britta, Schrezenmeier, Hubert, Ricklin, Daniel, Schmidt, Christoph Q.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2021
Ábhair:
Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959842/
https://ncbi.nlm.nih.gov/pubmed/33732239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.615748
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