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Broad distributions of transition-path times are fingerprints of multidimensionality of the underlying free energy landscapes

Recent single-molecule experiments have observed transition paths, i.e., brief events where molecules (particularly biomolecules) are caught in the act of surmounting activation barriers. Such measurements offer unprecedented mechanistic insights into the dynamics of biomolecular folding and binding...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Satija, Rohit, Berezhkovskii, Alexander M., Makarov, Dmitrii E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959536/
https://ncbi.nlm.nih.gov/pubmed/33087575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008307117
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