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Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography

Desmosomes are cell–cell junctions that link tissue cells experiencing intense mechanical stress. Although the structure of the desmosomal cadherins is known, the desmosome architecture—which is essential for mediating numerous functions—remains elusive. Here, we recorded cryo-electron tomograms (cr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sikora, Mateusz, Ermel, Utz H., Seybold, Anna, Kunz, Michael, Calloni, Giulia, Reitz, Julian, Vabulas, R. Martin, Hummer, Gerhard, Frangakis, Achilleas S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959525/
https://ncbi.nlm.nih.gov/pubmed/33067392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004563117
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