Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography

Desmosomes are cell–cell junctions that link tissue cells experiencing intense mechanical stress. Although the structure of the desmosomal cadherins is known, the desmosome architecture—which is essential for mediating numerous functions—remains elusive. Here, we recorded cryo-electron tomograms (cr...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Sikora, Mateusz, Ermel, Utz H., Seybold, Anna, Kunz, Michael, Calloni, Giulia, Reitz, Julian, Vabulas, R. Martin, Hummer, Gerhard, Frangakis, Achilleas S.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2020
Предметы:
Physical Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959525/
https://ncbi.nlm.nih.gov/pubmed/33067392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004563117
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