PLA2G6 guards placental trophoblasts against ferroptotic injury

The recently identified ferroptotic cell death is characterized by excessive accumulation of hydroperoxy-arachidonoyl (C20:4)- or adrenoyl (C22:4)- phosphatidylethanolamine (Hp-PE). The selenium-dependent glutathione peroxidase 4 (GPX4) inhibits ferroptosis, converting unstable ferroptotic lipid hyd...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Beharier, Ofer, Tyurin, Vladimir A., Goff, Julie P., Guerrero-Santoro, Jennifer, Kajiwara, Kazuhiro, Chu, Tianjiao, Tyurina, Yulia Y., St Croix, Claudette M., Wallace, Callen T., Parry, Samuel, Parks, W. Tony, Kagan, Valerian E., Sadovsky, Yoel
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959495/
https://ncbi.nlm.nih.gov/pubmed/33087576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009201117
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