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A high-affinity RBD-targeting nanobody improves fusion partner’s potency against SARS-CoV-2

A key step to the SARS-CoV-2 infection is the attachment of its Spike receptor-binding domain (S RBD) to the host receptor ACE2. Considerable research has been devoted to the development of neutralizing antibodies, including llama-derived single-chain nanobodies, to target the receptor-binding motif...

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Bibliografische gegevens
Gepubliceerd in:PLoS Pathog
Hoofdauteurs: Yao, Hebang, Cai, Hongmin, Li, Tingting, Zhou, Bingjie, Qin, Wenming, Lavillette, Dimitri, Li, Dianfan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959386/
https://ncbi.nlm.nih.gov/pubmed/33657135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009328
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