Silencing CDCA8 Suppresses Hepatocellular Carcinoma Growth and Stemness via Restoration of ATF3 Tumor Suppressor and Inactivation of AKT/β–Catenin Signaling

SIMPLE SUMMARY: Although the overexpression of CDCA8 is frequently observed in hepatocellular carcinoma (HCC) tissues, the functions of CDCA8 during HCC development remain to be clarified. The aim of our study was to investigate if targeting CDCA8 could affect liver tumor phenotypes in vitro and in...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Jeon, Taewon, Ko, Min Ji, Seo, Yu-Ri, Jung, Soo-Jung, Seo, Daekwan, Park, So-Young, Park, Keon Uk, Kim, Kwang Seok, Kim, Mikyung, Seo, Ji Hae, Park, In-Chul, Kim, Min-Ji, Bae, Jae-Hoon, Song, Dae-Kyu, Cho, Chi Heum, Lee, Jae-Ho, Lee, Yun-Han
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958635/
https://ncbi.nlm.nih.gov/pubmed/33801424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13051055
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