Spironolactone metabolite concentrations in decompensated heart failure: Insights from the ATHENA-HF trial.

BACKGROUND. In Aldosterone Targeted Neurohormonal Combined with Natriuresis Therapy in Heart Failure (ATHENA-HF), high-dose spironolactone (100 mg daily) did not improve efficacy endpoints over usual care (placebo or continued low-dose spironolactone [25 mg daily] in patients already receiving spiro...

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Bibliographic Details
Published in:Eur J Heart Fail
Main Authors: de Denus, Simon, Leclair, Grégoire, Dubé, Marie-Pierre, St-Jean, Isabelle, Zada, Yassamin Feroz, Oussaïd, Essaïd, Jutras, Martin, Givertz, Michael M., Mentz, Robert J., Tang, W. H. Wilson, Ferreira, João P, Rouleau, Jean, Butler, Javed, Kalogeropoulos, Andreas P.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958586/
https://ncbi.nlm.nih.gov/pubmed/32237012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejhf.1802
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