Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins

Mutations that activate LRRK2 protein kinase cause Parkinson's disease. We showed previously that Rab10 phosphorylation by LRRK2 enhances its binding to RILPL1, and together, these proteins block cilia formation in a variety of cell types, including patient derived iPS cells. We have used live-...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Sobu, Yuriko, Wawro, Paulina S., Dhekne, Herschel S., Yeshaw, Wondwossen M., Pfeffer, Suzanne R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958464/
https://ncbi.nlm.nih.gov/pubmed/33653948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005894118
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