Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils

The protein p53 is a crucial tumor suppressor, often called “the guardian of the genome”; however, mutations transform p53 into a powerful cancer promoter. The oncogenic capacity of mutant p53 has been ascribed to enhanced propensity to fibrillize and recruit other cancer fighting proteins in the fi...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Yang, David S., Saeedi, Arash, Davtyan, Aram, Fathi, Mohsen, Sherman, Michael B., Safari, Mohammad S., Klindziuk, Alena, Barton, Michelle C., Varadarajan, Navin, Kolomeisky, Anatoly B., Vekilov, Peter G.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2021
Предметы:
Physical Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958401/
https://ncbi.nlm.nih.gov/pubmed/33653952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015618118
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