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Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils
The protein p53 is a crucial tumor suppressor, often called “the guardian of the genome”; however, mutations transform p53 into a powerful cancer promoter. The oncogenic capacity of mutant p53 has been ascribed to enhanced propensity to fibrillize and recruit other cancer fighting proteins in the fi...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7958401/ https://ncbi.nlm.nih.gov/pubmed/33653952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015618118 |
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