IDO1 scavenges reactive oxygen species in myeloid-derived suppressor cells to prevent graft-versus-host disease

Tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1) also has an immunological function to suppress T cell activation in inflammatory circumstances, including graft-versus-host disease (GVHD), a fatal complication after allogeneic bone marrow transplantation (allo-BMT). Although the m...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Ju, Ji-Min, Nam, Giri, Lee, Young-Kwan, Jung, Minho, Chang, Hanna, Kim, Woojin, Shon, Woo Jeong, Lim, Ji Young, Kim, Joo Young, Chang, Jun, Min, Chang Ki, Lee, Dong-Sup, Choi, Kyungho, Shin, Dong-Mi, Choi, Eun Young
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958359/
https://ncbi.nlm.nih.gov/pubmed/33649207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011170118
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