Comparative parallel analysis of RNA ends identifies mRNA substrates of a tRNA splicing endonuclease-initiated mRNA decay pathway

Eukaryotes share a conserved messenger RNA (mRNA) decay pathway in which bulk mRNA is degraded by exoribonucleases. In addition, it has become clear that more specialized mRNA decay pathways are initiated by endonucleolytic cleavage at particular sites. The transfer RNA (tRNA) splicing endonuclease...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hurtig, Jennifer E., Steiger, Michelle A., Nagarajan, Vinay K., Li, Tao, Chao, Ti-Chun, Tsai, Kuang-Lei, van Hoof, Ambro
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958239/
https://ncbi.nlm.nih.gov/pubmed/33649230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020429118
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