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tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay
Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during the unfolded protein response (UPR). The UPR regulates the protein folding capacity of the endoplasmic reticulum (ER). ER stres...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6592678/ https://ncbi.nlm.nih.gov/pubmed/31237564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44199 |
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