Structural basis for recognition of distinct deaminated DNA lesions by endonuclease Q

Spontaneous deamination of DNA cytosine and adenine into uracil and hypoxanthine, respectively, causes C to T and A to G transition mutations if left unrepaired. Endonuclease Q (EndoQ) initiates the repair of these premutagenic DNA lesions in prokaryotes by cleaving the phosphodiester backbone 5′ of...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Shi, Ke, Moeller, Nicholas H., Banerjee, Surajit, McCann, Jennifer L., Carpenter, Michael A., Yin, Lulu, Moorthy, Ramkumar, Orellana, Kayo, Harki, Daniel A., Harris, Reuben S., Aihara, Hideki
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958190/
https://ncbi.nlm.nih.gov/pubmed/33658373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021120118
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