Reversal of the Inflammatory Responses in Fabry Patient iPSC-Derived Cardiovascular Endothelial Cells by CRISPR/Cas9-Corrected Mutation

The late-onset type of Fabry disease (FD) with GLA IVS4 + 919G > A mutation has been shown to lead to cardiovascular dysfunctions. In order to eliminate variations in other aspects of the genetic background, we established the isogenic control of induced pluripotent stem cells (iPSCs) for the ide...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Song, Hui-Yung, Yang, Yi-Ping, Chien, Yueh, Lai, Wei-Yi, Lin, Yi-Ying, Chou, Shih-Jie, Wang, Mong-Lien, Wang, Chien-Ying, Leu, Hsin-Bang, Yu, Wen-Chung, Chien, Chian-Shiu
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956852/
https://ncbi.nlm.nih.gov/pubmed/33673551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22052381
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