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Fatal Attraction: The Case of Toxic Soluble Dimers of Truncated PQBP-1 Mutants in X-Linked Intellectual Disability

The frameshift mutants K192S(fs*7) and R153S(fs*41), of the polyglutamine tract-binding protein 1 (PQBP-1), are stable intrinsically disordered proteins (IDPs). They are each associated with the severe cognitive disorder known as the Renpenning syndrome, a form of X-linked intellectual disability (X...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Chen, Yu Wai, Rahman, Shah Kamranur
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956452/
https://ncbi.nlm.nih.gov/pubmed/33668121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22052240
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