Precisely Fabricated Sulpiride-Loaded Nanolipospheres with Ameliorated Oral Bioavailability and Antidepressant Activity

BACKGROUND: Sulpiride (SUL), is a selective antidopaminergic drug that had extensive biological activities. However, its sparingly aqueous solubility and limited gastrointestinal permeability lead to scanty oral bioavailability which hinders its clinical efficacy. OBJECTIVE: SUL-loaded lipospheres (...

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Enregistré dans:
Détails bibliographiques
Publié dans:Int J Nanomedicine
Auteurs principaux: Mohyeldin, Salma M, Samy, Wael M, Ragab, Doaa, Abdelmonsif, Doaa A, Aly, Rania G, Elgindy, Nazik A
Format: Artigo
Langue:Inglês
Publié: Dove 2021
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955741/
https://ncbi.nlm.nih.gov/pubmed/33727812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S296726
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