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Interleukin 12p40 Deficiency Promotes Abdominal Aortic Aneurysm by Activating CCN2/MMP2 Pathways

BACKGROUND: Development of abdominal aortic aneurysm (AAA) is associated with proinflammatory cytokines including interleukin‐12 (IL12). Deficiency of interleukin 12p40 (IL12p40) increases localized fibrotic events by promoting TGFβ2 (transforming growth factor β)‐dependent anti‐inflammatory respons...

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Dades bibliogràfiques
Publicat a:J Am Heart Assoc
Autors principals: Sharma, Neekun, Hans, Chetan P.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955443/
https://ncbi.nlm.nih.gov/pubmed/33470127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.120.017633
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