Adeno-associated virus capsid assembly is divergent and stochastic

Adeno-associated viruses (AAVs) are increasingly used as gene therapy vectors. AAVs package their genome in a non-enveloped T = 1 icosahedral capsid of ~3.8 megaDalton, consisting of 60 subunits of 3 distinct viral proteins (VPs), which vary only in their N-terminus. While all three VPs play a role...

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Publicat a:Nat Commun
Autors principals: Wörner, Tobias P., Bennett, Antonette, Habka, Sana, Snijder, Joost, Friese, Olga, Powers, Thomas, Agbandje-McKenna, Mavis, Heck, Albert J. R.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955066/
https://ncbi.nlm.nih.gov/pubmed/33712599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21935-5
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