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CXCL10/CXCR3 Signaling in the DRG Exacerbates Neuropathic Pain in Mice

Chemokines and receptors have been implicated in the pathogenesis of chronic pain. Here, we report that spinal nerve ligation (SNL) increased CXCR3 expression in dorsal root ganglion (DRG) neurons, and intra-DRG injection of Cxcr3 shRNA attenuated the SNL-induced mechanical allodynia and heat hypera...

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Detalhes bibliográficos
Publicado no:Neurosci Bull
Main Authors: Kong, Yan-Fang, Sha, Wei-Lin, Wu, Xiao-Bo, Zhao, Lin-Xia, Ma, Ling-Jie, Gao, Yong-Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955022/
https://ncbi.nlm.nih.gov/pubmed/33196963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-020-00608-1
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