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P2X7 is a cytotoxic receptor….maybe not: implications for cancer

The tumor microenvironment is rich in extracellular ATP. This nucleotide affects both cancer and infiltrating immune cell responses by acting at P2 receptors, chiefly P2X7. ATP is then degraded to generate adenosine, a very powerful immunosuppressant. The purinergic hypothesis put forward by Geoff B...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Purinergic Signal
1. Verfasser: Di Virgilio, Francesco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Netherlands 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955003/
https://ncbi.nlm.nih.gov/pubmed/33011962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-020-09735-w
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