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P2X7 is a cytotoxic receptor….maybe not: implications for cancer

The tumor microenvironment is rich in extracellular ATP. This nucleotide affects both cancer and infiltrating immune cell responses by acting at P2 receptors, chiefly P2X7. ATP is then degraded to generate adenosine, a very powerful immunosuppressant. The purinergic hypothesis put forward by Geoff B...

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Detalhes bibliográficos
Publicado no:Purinergic Signal
Autor principal: Di Virgilio, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955003/
https://ncbi.nlm.nih.gov/pubmed/33011962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-020-09735-w
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