Augmented antibody-based anticancer therapeutics boost neutrophil cytotoxicity

Most clinically used anticancer mAbs are of the IgG isotype, which can eliminate tumor cells through NK cell–mediated antibody-dependent cellular cytotoxicity and macrophage-mediated antibody-dependent phagocytosis. IgG, however, ineffectively recruits neutrophils as effector cells. IgA mAbs induce...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Heemskerk, Niels, Gruijs, Mandy, Temming, A. Robin, Heineke, Marieke H., Gout, Dennis Y., Hellingman, Tessa, Tuk, Cornelis W., Winter, Paula J., Lissenberg-Thunnissen, Suzanne, Bentlage, Arthur E.H., de Donatis, Marco, Bögels, Marijn, Rösner, Thies, Valerius, Thomas, Bakema, Jantine E., Vidarsson, Gestur, van Egmond, Marjolein
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954609/
https://ncbi.nlm.nih.gov/pubmed/33561014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134680
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