Afucosylated IgG Targets FcγRIV for Enhanced Tumor Therapy in Mice

SIMPLE SUMMARY: Cancer treatments are increasingly based on therapeutic antibodies to clear tumors. While in vivo mouse models are useful to predict effectiveness of human antibodies it is not completely clear how useful these models are to test antibodies engineered with enhanced effector functions...

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Dettagli Bibliografici
Pubblicato in:Cancers (Basel)
Autori principali: Braster, Rens, Bögels, Marijn, Benonisson, Hreinn, Wuhrer, Manfred, Plomp, Rosina, Bentlage, Arthur E. H., Korthouwer, Rianne, Visser, Remco, Verbeek, J. Sjef, van Egmond, Marjolein, Vidarsson, Gestur
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8156657/
https://ncbi.nlm.nih.gov/pubmed/34069226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13102372
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