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Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis

Monocyte homing to the liver and adhesion to the liver sinusoidal endothelial cells (LSECs) are key elements in nonalcoholic steatohepatitis (NASH) pathogenesis. We reported previously that VCAM-1 mediates monocyte adhesion to LSECs. However, the pathogenic role of VCAM-1 in NASH is unclear. Herein,...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Furuta, Kunimaro, Guo, Qianqian, Pavelko, Kevin D., Lee, Jeong-Heon, Robertson, Keith D., Nakao, Yasuhiko, Melek, Jan, Shah, Vijay H., Hirsova, Petra, Ibrahim, Samar H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954604/
https://ncbi.nlm.nih.gov/pubmed/33476308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143690
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