Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models

Medulloblastoma is an aggressive pediatric brain tumor that can be driven by misactivation of the Hedgehog (HH) pathway. CDK6 is a critical effector of oncogenic HH signaling, but attempts to target the HH pathway in medulloblastoma have been encumbered by resistance to single-agent molecular therap...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Daggubati, Vikas, Hochstelter, Jordan, Bommireddy, Anirudh, Choudhury, Abrar, Krup, Alexis Leigh, Kaur, Pervinder, Tong, Pakteema, Li, Amy, Xu, Libin, Reiter, Jeremy F., Raleigh, David R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2021
Schlagworte:
Concise Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954583/
https://ncbi.nlm.nih.gov/pubmed/33476305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI141171
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