Injury-mediated stiffening persistently activates muscle stem cells through YAP and TAZ mechanotransduction

The skeletal muscle microenvironment transiently remodels and stiffens after exercise and injury, as muscle ages, and in myopathic muscle; however, how these changes in stiffness affect resident muscle stem cells (MuSCs) remains understudied. Following muscle injury, muscle stiffness remained elevat...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Silver, Jason S., Günay, K. Arda, Cutler, Alicia A., Vogler, Thomas O., Brown, Tobin E., Pawlikowski, Bradley T., Bednarski, Olivia J., Bannister, Kendra L., Rogowski, Cameron J., Mckay, Austin G., DelRio, Frank W., Olwin, Bradley B., Anseth, Kristi S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954458/
https://ncbi.nlm.nih.gov/pubmed/33712460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe4501
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