Transcriptional analysis of islets of Langerhans from organ donors of different ages

Insulin secretion is impaired with increasing age. In this study, we aimed to determine whether aging induces specific transcriptional changes in human islets. Laser capture microdissection was used to extract pancreatic islet tissue from 37 deceased organ donors aged 1–81 years. The transcriptomes...

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Pubblicato in:PLoS One
Autori principali: Seiron, Peter, Stenwall, Anton, Hedin, Anders, Granlund, Louise, Esguerra, Jonathan Lou S., Volkov, Petr, Renström, Erik, Korsgren, Olle, Lundberg, Marcus, Skog, Oskar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954335/
https://ncbi.nlm.nih.gov/pubmed/33711030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0247888
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