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Biological impact of mutually exclusive exon switching

Alternative splicing can expand the diversity of proteomes. Homologous mutually exclusive exons (MXEs) originate from the same ancestral exon and result in polypeptides with similar structural properties but altered sequence. Why would some genes switch homologous exons and what are their biological...

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Bibliografiska uppgifter
I publikationen:PLoS Comput Biol
Huvudupphovsmän: Lam, Su Datt, Babu, M. Madan, Lees, Jonathan, Orengo, Christine A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954323/
https://ncbi.nlm.nih.gov/pubmed/33651795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008708
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