Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling

Hepatocellular carcinoma (HCC) remains one of the deadliest malignancies worldwide. One major obstacle to treatment is a lack of effective molecular-targeted therapies. In this study, we find that EphA2 expression and signaling are enriched in human HCC and associated with poor prognosis. Loss of Ep...

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Vydáno v:Cell Rep
Hlavní autoři: Wang, Hao, Hou, Wei, Perera, Aldeb, Bettler, Carlee, Beach, Jordan R., Ding, Xianzhong, Li, Jun, Denning, Mitchell F., Dhanarajan, Asha, Cotler, Scott J., Joyce, Cara, Yin, Jun, Ahmed, Fowsiyo, Roberts, Lewis R., Qiu, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954228/
https://ncbi.nlm.nih.gov/pubmed/33626345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108765
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