IL-11 antagonist suppresses Th17 cell-mediated neuroinflammation and demyelination in a mouse model of relapsing-remitting multiple sclerosis

IL-11 induced differentiation and expansion of Th17 cells in patients with early relapsing-remitting multiple sclerosis (RRMS). In mice with relapsing-remitting experimental autoimmune encephalomyelitis (RREAE), IL-11 exacerbated disease, induced demyelination in the central nervous system (CNS), in...

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Vydáno v:Clin Immunol
Hlavní autoři: Zhang, Xin, Kiapour, Nazanin, Kapoor, Sahil, Merrill, Joseph R., Xia, Yongjuan, Ban, Woomi, Cohen, Stephanie M., Midkiff, Bentley R., Jewells, Valerie, Shih, Yen-Yu I., Markovic-Plese, Silva
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953940/
https://ncbi.nlm.nih.gov/pubmed/30149119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2018.08.006
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