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Activated IL-1RI Signaling Pathway Induces Th17 Cell Differentiation via Interferon Regulatory Factor 4 Signaling in Patients with Relapsing-Remitting Multiple Sclerosis

IL-1β plays a crucial role in the differentiation of human Th17 cells. We report here that IL-1RI expression is significantly increased in both naive and memory CD4(+) T cells derived from relapsing-remitting multiple sclerosis (RR MS) patients in comparison to healthy controls. Interleukin 1 recept...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Sha, Yonggang, Markovic-Plese, Silva
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126112/
https://ncbi.nlm.nih.gov/pubmed/27965670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00543
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