Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence

The autoimmune polyglandular syndrome type 1 (APS1) is caused by pathogenic variants of the autoimmune regulator (AIRE) gene, located in the chromosomal region 21q22.3. The related protein, AIRE, enhances thymic self-representation and immune self-tolerance by localization to chromatin and anchorage...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Perniola, Roberto, Fierabracci, Alessandra, Falorni, Alberto
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953157/
https://ncbi.nlm.nih.gov/pubmed/33717087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.606860
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