Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes

Myeloid cell arginase-mediated arginine depletion with consecutive inhibition of T cell functions is a key component of tumor immune escape. Both, granulocytic myeloid-derived suppressor cells (G-MDSC) and conventional mature human polymorphonuclear neutrophil granulocytes (PMN) express high levels...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Vonwirth, Verena, Bülbül, Yagmur, Werner, Anke, Echchannaoui, Hakim, Windschmitt, Johannes, Habermeier, Alice, Ioannidis, Sonia, Shin, Niu, Conradi, Roland, Bros, Matthias, Tenzer, Stefan, Theobald, Matthias, Closs, Ellen Ildicho, Munder, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7952869/
https://ncbi.nlm.nih.gov/pubmed/33717053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.617699
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