Cycling hypoxia selects for constitutive HIF stabilization

Tumors experience temporal and spatial fluctuations in oxygenation. Hypoxia inducible transcription factors (HIF-α) respond to low levels of oxygen and induce re-supply oxygen. HIF-α stabilization is typically facultative, induced by hypoxia and reduced by normoxia. In some cancers, HIF-α stabilizat...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Pressley, Mariyah, Gallaher, Jill A., Brown, Joel S., Tomaszewski, Michal R., Borad, Punit, Damaghi, Mehdi, Gillies, Robert J., Whelan, Christopher J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7952589/
https://ncbi.nlm.nih.gov/pubmed/33707510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85184-8
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